The Haemophilia Osteoporosis Registry (THOR): identifying mechanisms of bone loss in patients with haemophilia A

Fracture incidence is increased in patients with haemophilia (PWH), with disease severity affecting fracture risk. The underlying mechanisms of increased fracture risk in PWH is unknown, as are the age at which bone loss begins and whether this is greater than in the general population. Therefore, the primary aim is to identify mechanisms of bone loss in patients with haemophilia A. Secondary aims include: assessing lean mass, muscle strength and physical function, and their effects on bone health; and investigating joint health and bone parameters at the knee, and whether these are risk factors for osteoporosis and fracture.