Disorders of the epididymis and vas deferens contribute to infertility, recurrent infections, chronic inflammation and pain. Evidence suggests that interactions between the inflammatory cytokine, activin and its binding protein, follistatin, play fundamental roles in creating the unique functions of the epididymis and vas, and that defects in activin-follistatin interactions underlie disease in these tissues. In this project, the student will investigate activin and its regulation by follistatin in control of the development and mature functions of the epididymis and vas deferens. This project could also include studies of the role of activin in controlling inflammation and immunity in the male tract. Students undertaking this project at postgraduate level may also have the opportunity to undertake 6 – 12 months collaborative research at the Justus Liebig University in Giessen, Germany, with the option of studying for a joint degree award from both Universities.
Inflammation, men's health, fertility, chronic pain, epididymis
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research
Masters by research
Monash Health Translation Precinct (Monash Medical Centre)