Expanding our understanding of uterine endometrial regeneration

The inner lining of the uterus (endometrium) is a highly regenerative tissue, being shed and regrown every month during the menstrual cycle. The key factors underpinning this regeneration remain poorly understood and can have diverse implications for overall health, as well as disorders including heavy menstrual bleeding, endometriosis, thin endometrium, female infertility, miscarriage and pregnancy complications. This study aims to improve our understanding of vital factors that promote healthy endometrial regeneration, including assessments of blood vessels, stem cells and immune cells. This project will employ novel animal models, as well as human samples. We use a variety of techniques, including flow cytometry, single cell RNA sequencing, qRT-PCR, Western blotting, immunofluorescence, in situ hybridisation, 3D confocal imaging and ELISA.