Stroke is a highly prevalent and debilitating brain injury caused by the sudden impairment of blood flow to the brain. Despite the brain injury, it is beginning to emerge that infections is the leading cause of death in the stroke patients. Currently, there is limited strategies offered to patients focused at managing their infectious complications in the aftermath of stroke. Prophylactic antibiotics may be a viable option for treatment, however with the escalating problem of increased antibiotic-resistance strains of pathogens, there is an urgent need to introduce more effective therapeutic approaches. In our previous work, we identified the mechanism behind impaired function of a group of specialized immune cells responsible for infections after stroke. With this as premise, we propose to test novel therapeutic strategies that aim to reset host immunity to reduce infections without exacerbating injury to the brain after stroke. This information is essential as we progress towards translating basic research findings to design better targeted treatments for stroke patients, ultimately improving patient outcomes.
stroke, neuroinflammation, gut, infection
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Medicine - Monash Medical Centre
Top-up scholarship funding available
Monash Health Translation Precinct (Monash Medical Centre)