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Endometrial organoids: novel tools for precision gynaecological medicine

Description 
Organoids are miniature organs cultured in a dish that enable disease modelling and development of precision medicine. This project will utilize this exciting tool to generate organoids from human and mice to study endometrial stem cell biology and its role in the formation of endometriosis. Endometriosis is a disease affecting 10% of women, where by endometrial cells form lesions in pelvic cavity, causing pain, disease and infertility. This project will generate a new system for investigating the causes of endometriosis and a patient-derived biobank for disease phenotypic profiling, drug discovery and precision medicine. Techniques include tissue culture, organoids, fluorescence activated cell sorting, in vitro assays, immuno-fluorescence and mouse models. Techniques employed can be tailored to suit the interests of the student.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
Endometriosis, flow cytometry, stem cells, diagnostics, organoids, precision medicine
Available options 
PhD/Doctorate
Masters by research
Honours
BMedSc(Hons)
Time commitment 
Full-time
Top-up scholarship funding available 
No
Physical location 
Monash Health Translation Precinct (Monash Medical Centre)
Co-supervisors 
Dr 
Caitlin Filby

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