Organoids are miniature organs cultured in a dish that enable disease modelling and development of precision medicine. This project will utilize this exciting tool to generate organoids from human and mice to study endometrial stem cell biology and its role in the formation of endometriosis. Endometriosis is a disease affecting 10% of women, where by endometrial cells form lesions in pelvic cavity, causing pain, disease and infertility. This project will generate a new system for investigating the causes of endometriosis and a patient-derived biobank for disease phenotypic profiling, drug discovery and precision medicine. Techniques include tissue culture, organoids, fluorescence activated cell sorting, in vitro assays, immuno-fluorescence and mouse models. Techniques employed can be tailored to suit the interests of the student.
Endometriosis, flow cytometry, stem cells, diagnostics, organoids, precision medicine
Masters by research
Top-up scholarship funding available
Monash Health Translation Precinct (Monash Medical Centre)