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Elucidating the mechanistic link between the circadian clock and cancer

Description 
Circadian clocks generate daily rhythms to enhance the fitness of virtually all living organisms. Disruption of these rhythms has been implicated in increased cancer risks. However, how dysregulation of circadian rhythms increases cancer risks remains poorly understood. This research project will investigate the mechanistic link between the mammalian circadian clock and cancer. This research holds the long-term potential to combine chronotherapy (timing of therapeutic administration) with immunotherapy and traditional methods such as radiation and chemotherapy to combat cancer. This research program will leverage state-of-art biophysical techniques, including cryo-EM, NMR, and X-ray crystallography.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
cryogenic electron microscopy (cryo-EM), crystallography, structural biology, cancer, circadian clock
Available options 
PhD/Doctorate
Honours
Time commitment 
Full-time
Top-up scholarship funding available 
No
Physical location 
18 Innovation Walk
Co-supervisors 
Dr 
Tyler Chang

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