Inflammation in the testis and epididymis can impair male fertility, and epididymal obstruction is a major cause of infertility following infection and inflammation of the male tract. Activin has both proinflammatory and immunoregulatory functions, but until now, the role of activin in testicular and epididymal inflammation has been very poorly investigated. This project examines activin and its binding protein, follistatin in regulating inflammation and fibrosis caused by infection and autoimmunity in the male tract. These studies will also assess the potential for exogenous follistatin to serve as a therapeutic intervention for these conditions. Students undertaking this project at postgraduate level may also have the opportunity to undertake 6 – 12 months collaborative research at the Justus Liebig University in Giessen, Germany, with the option of studying for a joint degree award from both Universities.
Inflammation, men's health, infertility, testis, epididymis, immunoregulation
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research
Masters by research
Monash Health Translation Precinct (Monash Medical Centre)