Developing biospectroscopy as a rapid point-of-care diagnostic for gastrointestinal disease

Spectroscopy, an analytical chemical technique is an attractive approach for analysing human disease for biomarker discovery. Biospecimens can be imaged label-free, without destruction and provide rapid, reproducible results. This project involves applying modalities of vibrational spectroscopy for various human gastrointestinal diseases to develop rapid point-of-care diagnostics for clinical management. The project will involve optimising portable bed-side spectrometer models for use on human biospecimens, learning data pre-processing and analysis techniques with machine learning and modelling. This can be applied to a wide range of gastrointestinal conditions with unmet clinical needs. My current focus is on immune-mediated gastrointestinal conditions and I have published our proof-of-concept work and recently presented our research using infra-red spectroscopy to characterise inflammatory bowel disease (IBD) and assess biomarkers for treatment response and disease states at international IBD conferences. Please contact me to discuss the project further.