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Defining drivers of metastatic lung cancer.

Lung cancer patient's die from metastatic disease, not primary disease. In the case of small cell lung cancer the brain is a primary site of metastatic spread and if detected alters treatment approach and predicted outcomes. However, the mechanisms that drive lung cancer to spread specifically to the brain are unknown and models do not exist to enable us to identify better treatments for these patients. This project will take advantage the preclinical mouse models my lab has developed and unbiased genome wide screening technologies to identify genetic drivers of brain metastasis.
Essential criteria: 
Minimum entry requirements can be found here:
Lung cancer, metastasis, CRISPR screening
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Molecular and Translational Sciences
Available options 
Time commitment 
Physical location 
Monash Health Translation Precinct (Monash Medical Centre)
Assoc Prof 
Jason Cain

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