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Decoding the significance of endometriosis risk

Description 
Endometriosis is a devastating chronic disease affecting 10% of girls and women, where cells of endometrial histology form lesions throughout the pelvic cavity, causing pain, disease and infertility. The causes are unknown, although genetic risk plays a role. Current treatments are often ineffective with side effects. Recent work by us and our collaborator Prof Grant Montgomery at UQ (Sapkota, 2017) indicate that endometrial stem/progenitor cells may cause lesion formation and this may be due to single nucleotide polymorphisms (SNPs) in over 14 regions of the genome that are associated with increased risk of endometriosis. This project aims to decode the biological significance of these SNPs in endometriosis by isolating stem/progenitor cell populations in women with endometriosis. The study will use tissue culture, fluorescent activated cell sorting, organoid culture and single cell RNA sequencing, mouse models. Techniques employed can be tailored to suit the interests of the student. This project has international funding.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
Endometriosis, organoids, single cell sequencing, stem cells, genetics
Available options 
PhD/Doctorate
Masters by research
Honours
BMedSc(Hons)
Time commitment 
Full-time
Top-up scholarship funding available 
No
Physical location 
Monash Health Translation Precinct (Monash Medical Centre)
Co-supervisors 
Dr 
Caitlin Filby

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