You are here

A "cure" for autoimmune diseases. Development of new approaches to tolerance induction in mice

Description 
We wish to revolutionise the treatment of autoimmune diseases. We are hoping to devise strategies to eliminate harmful auto reactive cells using depleting monoclonal antibodies to T cell molecules like CXCR3 and CCR6. We will restore immunological tolerance using the gut microbiome and metabolites and special nutrition approaches. See Marino et al., Nature Immunology 2017. If successful, this approach will lead to reversal of autoimmune disease and re-establishment of tolerance. Part of the project will also involve analysis of the gut microbiome and how this can be used to restore tolerance.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
immune tolerance. short chain fatty acids, autoimmune disease, microbiome, CXCR3, CCR6, therapy,
School 
Biomedicine Discovery Institute (School of Biomedical Sciences)Microbiology
Available options 
PhD/Doctorate
Honours
Time commitment 
Full-time
Top-up scholarship funding available 
Yes
Year 1: 
$6000
Year 2: 
$6000
Year 3: 
$6000
Year 4: 
$6000
Physical location 
15 Innovation Walk

Want to apply for this project? Submit an Expression of Interest by clicking on Contact the researcher.