A "cure" for autoimmune diseases. Development of new approaches to tolerance induction in mice

We wish to revolutionise the treatment of autoimmune diseases. We are hoping to devise strategies to eliminate harmful auto reactive cells using depleting monoclonal antibodies to T cell molecules like CXCR3 and CCR6. We will restore immunological tolerance using the gut microbiome and metabolites and special nutrition approaches. See Marino et al., Nature Immunology 2017. If successful, this approach will lead to reversal of autoimmune disease and re-establishment of tolerance. Part of the project will also involve analysis of the gut microbiome and how this can be used to restore tolerance.