Description
Long bones grow by forming a cartilage template that provides a scaffold to be replaced by mineralised bone. Developmental perturbations in this cartilage are compensated for by surrounding cells. Based on scRNA-seq data, we hypothesize that the injured cartilage has altered lipid metabolism, which alters key signalling pathways in the responding cells. We will quantify the expression of key biosynthetic enzymes and responding signalling pathways, determine the spatial distribution of free cholesterol and use ex vivo cultures to test the role of key candidates in bone growth
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
developmental biology, regenerative medicine, metabolism, stem cells, catch-up growth, limb development, bone growth, growth plate, mouse models
School
Australian Regenerative Medicine Institute (ARMI)
Available options
PhD/Doctorate
Masters by research
Honours
Short projects
Time commitment
Full-time
Part-time
Top-up scholarship funding available
No
Physical location
15 Innovation Walk
Research webpage
Co-supervisors
Dr
Chee Ho H'ng