Characterising Meningeal Plasma Cells as Gatekeepers of Brain Immunity

The brain is traditionally viewed as an immune‑privileged organ, but recent discoveries have revealed that its surrounding membranes—the meninges—host a surprisingly active immune ecosystem. Among the most intriguing residents of this niche are plasma cells, the antibody‑secreting cells best known for protecting mucosal surfaces and the bloodstream. This project investigates how these meningeal plasma cells form and persist, in order to defend the central nervous system (CNS) from infection. This research aims to define the fundamental biology of plasma cells that reside at CNS borders. Key questions include: -- How long do they persist, and what maintains them? -- Where do meningeal plasma cells come from? -- How do these cells change during immunisation, infection or inflammation? Neuroinvasive pathogens such as HSV, West Nile virus, and Streptococcus pneumoniae often enter through peripheral routes before breaching CNS barriers. Plasma cells positioned at the meninges may act as a first line of humoral defence, producing antibodies exactly where they are needed to intercept pathogens before they reach the brain. Defining how these cells work could lead to new approaches for preventing CNS infections and modulating harmful antibody responses in autoimmune diseases. Depending on your level (Honours, Masters, PhD), the project may include: -- Advanced flow cytometry and cell sorting -- Mouse models of plasma‑cell fate mapping -- RNA‑seq and BCR repertoire sequencing -- Imaging of CNS barrier tissues Who this project suits: Students interested in immunology and neuroimmunology with curiosity and passion for exploring new field of research.