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Characterisation of innate immune responses during exacerbation of asthma and COPD

Description 
Our research is focussed on understanding how viruses and bacteria cause exacerbations of inflammatory lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Previous studies in our laboratory have demonstrated that reduced innate immune responses contribute to enhanced virus infection in asthmatic persons and in a mouse model of influenza A infection. We have also demonstrated the detrimental effect of glucocorticosteroids on viral infection in these diseases (Thomas et al., Am J Resp Cell Mol Biol, 2009, Thomas et al., Sci Rep, 2014). Further studies using validated primary cell culture models and various mouse models of viral and bacterial infection are examining the mechanisms contributing to reduced host immune responses and potential therapeutic strategies to counter these adverse effects.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
asthma, virus, bacteria, innate immunity, mouse models, infection
School 
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Molecular and Translational Sciences
Available options 
PhD/Doctorate
Honours
BMedSc(Hons)
Time commitment 
Full-time
Top-up scholarship funding available 
No
Physical location 
Monash Health Translation Precinct (Monash Medical Centre)
Co-supervisors 
Prof 
Philip Bardin

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