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Change in knee structure in healthy women and the relationship to bone health

Knee osteoarthritis is a major public health problem. The role of bone, integral to the pathogenesis of knee OA, is receiving increasing attention as bone changes have been related to change in knee symptoms and disease progression. This is of particular importance, as bone metabolism may be a useful target for affecting this disease, in contrast to cartilage, which is less metabolically active. The relationship between bone health and change in knee structure in a healthy population is unknown. This study aims to characterise change in knee structure in a healthy younger asymptomatic population of women, and identify how this relates to factors affecting bone health. This study will utilise data from a community based study of women, from the Geelong Osteoporosis study. This study has data on 160 women, aged 20 – 62, who were recruited from the electoral roll, to be representative of the Australian female population. The aim of this study is to examine how the change in knee structural changes over 2 years relates to factors affecting bone health. The right knee of all women was imaged using Magnetic Resonance Imaging at 2 time points, 2 years apart. From the MRI images, measures of knee structure at baseline and 2 years later have been made using validated methods. Measures of bone health have been made at baseline, including bone mineral density. Analyses relating change in knee structure to risk factors for bone health will be performed using linear/logistic regression, adjusting for potential confounders.
Essential criteria: 
Minimum entry requirements can be found here:
Knee osteoarthritis
School of Public Health and Preventive Medicine
Available options 
Time commitment 
Physical location 
553 St Kilda Rd, Melbourne (adjacent to The Alfred)

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