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Carbapenem resistance in the Australian setting: using genomics to understand the spread of deadly pathogens

Description 
Multi-drug resistance in Gram-negative bacteria (MDR-GNB) is a global health challenge that threatens many medical advances. Infections caused by MDR-GNB such as carbapenem-resistant Enterobacteriaceae (CRE) have a high morbidity and mortality that exceeds 50%. CRE are increasingly prevalent in Australia and have been implicated in several outbreaks. This project aims to use innovative next generation sequencing techniques to dissect the rise of CRE in the Australian hospital setting. Using a collection of bacterial isolates dating back >15 years, we will study how carbapenem resistance has evolved, in particular through close analysis of plasmid dynamics and interspecies spread. This genomic data will be linked to clinical data to better understand the risk factors for CRE colonisation and infection, as well as analyse spread of CRE in the hospital setting.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
Antimicrobial resistance; Carbapenem resistance; Superbugs; Genomics; Microbiology
School 
Central Clinical School » Infectious Diseases
Available options 
PhD/Doctorate
Masters by research
Masters by coursework
Honours
BMedSc(Hons)
Short projects
Time commitment 
Full-time
Part-time
Top-up scholarship funding available 
No
Physical location 
Burnet Institute
Co-supervisors 
Prof 
Anton Peleg

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