Interventions for the prevention and treatment of hyperglycaemia in pregnancy Prof. Helena Teede and Dr Aya Mousa Gestational diabetes mellitus (GDM) is a common metabolic disorder affecting 15-20% of pregnancies, and its incidence is rising in line with maternal obesity and advanced childbearing age. GDM, which is characterised by insulin resistance, is a known risk factor for adverse pregnancy outcomes including preeclampsia, macrosomia, and fetal abnormalities. It is also the strongest population predictor of type 2 diabetes (T2D), where up to 63% of women with GDM will develop T2D within 5 years of pregnancy, resulting in further healthcare costs and complications including cardiovascular diseases (CVD) later in life. New research has yielded the concept that ‘diabetes begets diabetes’, suggesting that GDM not only predisposes the mother, but also the infant, to diabetes and CVD later in life. An improved understanding of the mechanisms underpinning GDM development and the efficacy of current interventions are therefore of paramount importance to facilitate early detection and prevention of GDM and its sequelae. This project encompasses multiple aims as follows: - to advance understanding of the pathophysiology of hypergylcaemia in pregnancy and GDM; - to examine and identify biomarkers of GDM to facilitate early identification and prevention; - to evaluate the efficacy of interventions (dietary, lifestyle, and pharmaceutical) targeted at preventing and treating hyperglycaemia in pregnancy; and - ultimately, to translate research findings into clinical practice to improve pregnancy outcomes and long-term maternal health. To achieve these aims, the project will encompass a multi-disciplinary approach with ample opportunities for students to obtain key research knowledge and skills. Multiple methodologies will be utilized to achieve the research aims, spanning across the research continuum from mechanistic and epidemiological research, to clinical trials, large-scale meta-analyses, and translational activities.
metformin, diabetes, gestational diabetes, GDM, pregnancy, reproductive health, obstetrics, gynecology
School of Public Health and Preventive Medicine
Masters by Research
Top-up scholarship funding available
Monash Centre for Health Research and Implementation (MCHRI), Clayton