Biomarkers of metabolic and reproductive disorders

Led by Dr. Aya Mousa and Prof. Helena Teede Major current projects include: - Identification of key lipid signatures and their associations with clinical and cardiometabolic features of polycystic ovary syndrome - Plasma lipidomic signatures for risk prediction and prevention of gestational diabetes - Metabolic insulin resistant conditions including polycystic ovary syndrome, gestational diabetes, and pre-existing diabetes: breastmilk composition and biomarkers and their relationship with maternal and fetal health - Vitamin D binding protein in polycystic ovary syndrome, pregnancy and reproductive health (including fertility) - Microbiome and inflammation: relationships with insulin resistance in obesity and PCOS Inflammation markers and adipokines in obesity, type 2 diabetes, gestational diabetes and heart failure - Epigenetic and biomarker studies for gestational diabetes and adverse pregnancy outcomes using departmental bio-banked samples collected from >1000 pregnant women with and without gestational diabetes These projects encompass a multidisciplinary approach with ample opportunities for students to obtain key research knowledge and skills. Multiple methodologies will be utilised to achieve the research aims, spanning across the research continuum from mechanistic and epidemiological research, to clinical trials, large-scale meta-analyses, and translational activities. Ideally, this work is suited for students with an interest in metabolism and reproductive health and with a passion for delivering research with impact. Given the timelines for most of these projects, Honours or Masters students may only be considered if they plan to progress to a PhD.