This project will examine serum and saliva for endometriosis biomarkers that diagnose and stratify for disease severity and related infertility. The project will profile glycosylation changes to the proteins produced by the endometrium lining of the uterus, to identify the unique disease associated glycoforms. The project will utilise lectins and agglutinins as tools to examine both human endometrial tissue and secretions using histochemical and western blot techniques. Complimenting this will be an affinity-proteomic study in collaboration with Baker IDI to identify individual protein glycosylation changes for subsequent validation in an antibody-based assay of patient samples.
endometriosis, diagnostic, biomarkers, glycosylation
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Molecular and Translational Sciences
Masters by research
Top-up scholarship funding available
Monash Medical Centre Clayton