Biodiversity of mitochondrial respiratory complexes - What drives the evolution of bioenergetic molecular machines?

Mitochondria are essential for metabolism, signalling, and adaptation, yet the molecular basis for their extraordinary diversity remains poorly understood. This project will uncover how mitochondrial energy-transducing complexes evolved across the diversity of eukaryotic life. You would use advanced cryogenic electron microscopy (cryo-EM), organelle and membrane-protein isolation, comparative evolutionary analysis and functional characterization via spectroscopic enzyme activity assays and respirometry. This research will reveal how changes in protein structure and lipid environment shape respiratory efficiency, regulation, and resilience under environmental stress. These insights will define universal principles that govern energy conversion in living systems and provide a framework for understanding how complex life arose and diversified on Earth. Only extremely dedicated and driven students with excellent oral and written communication skills should apply.