Autoimmune vasculitis caused by loss of tolerance to neutrophil antigens (ANCA-associated vasculitis) results in severe kidney and respiratory tract disease. There are two main autoantigens involved, myeloperoxidase (MPO) and proteinase-3. Current treatments are relatively non specific and come with significant side effects. There are currently no antigen specific treatments. We are an internationally recognised group researching the causes of these severe autoimmune diseases so that more specific and effective treatments can be developed and used. Projects in this area examine how we can translate our discoveries on the parts of MPO that cause loss of tolerance into new and more effective treatments. Projects will use pre-clinical mouse models of anti-MPO glomerulonephritis (ANCA-associated vasculitis) together with human blood samples from the Monash Vasculitis Registry and Biobank, led and run by Professor Kitching as part of his clinical work at Monash Health.
vasculitis, autoimmunity, myeloperoxidase, kidney disease, glomerulonephritis, tolerance
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Medicine - Monash Medical Centre
Masters by research
Joint PhD/Exchange Program
Top-up scholarship funding available
Monash Health Translation Precinct (Monash Medical Centre)