Preeclampsia is a pregnancy disorder characterised by hypertension with proteinuria, maternal organ dysfunction or fetal growth restriction. Each year preeclampsia is the cause of death in over 60,000 women and in more than 500,000 babies globally. The pathophysiological mechanisms underlying the disease are not entirely clear, however we do know that placental (trophoblast) cells are major contributors to this disorder. Therefore, the trophoblast cells of the placenta are very important research tools to help us better understand preeclampsia and to help us identify potential treatments for this disorder. This project will involve the collection and culturing of trophoblast cells from the placenta of women undergoing elective caesarian. Then, survival and viability of these cells will be assessed after treatment with new compounds that could be future treatments for preeclampsia.
Pregnancy, preeclampsia, placenta, trophoblast, cell culture
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Obstetrics and Gynaceology
Monash Health Translation Precinct (Monash Medical Centre)