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Assessing the Beneficial Affects of Cruciferous Vegetable Extracts

Description 
Early in pregnancy, the maternal vasculature undergoes dramatic adaptations to help support both the mother and the developing baby throughout pregnancy. However, failure of the maternal vasculature to fully adapt can result in the pregnancy disease known as pre-eclampsia (PE). PE affects approximately 1/20 pregnancies and is a leading cause of maternal and foetal morbidity and mortality worldwide. Unfortunately, disease severity often results in premature babies. Recently, it has become apparent how important the maternal vasculature is for disease development, making it a target to alleviate the clinical symptoms of PE and prolong pregnancy. Cruciferous vegetables, such as broccoli, provide a variety of beneficial health effects. So far, evidence suggests that novel compounds found in green leafy vegetables may have beneficial affects throughout the body, including the vasculature. Therefore, this project aims to identify whether these extracts can promote systemic health and be potential novel treatments for women with pre-eclampsia.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
pregnancy; pre-eclampsia; vascular dysfunction; wire myography; vascular reactivity
School 
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research
Available options 
PhD/Doctorate
Honours
Time commitment 
Full-time
Part-time
Top-up scholarship funding available 
No
Physical location 
Monash Health Translation Precinct (Monash Medical Centre)
Co-supervisors 
Prof 
Euan Wallace

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