Psoriasis is a skin autoimmune disease that affects 2-3% of the global population. Around half of the patients carry the major risk gene for developing the disease: Human Leukocyte Antigen-C*06:02 (HLA-Cw6). The function of HLA molecules is to present little protein snippets (peptide antigens) to immune cells, e.g. T cells. The immune cells, in turn, decide whether the presented antigen is harmless and can be ignored or poses a danger and needs dealing with. In order to understand closer the role of T cells and other immune cells in inflammatory skin conditions like psoriasis, we apply the new technology of spatial transcriptomics to interrogate cell-cell interactions in skin during steady state and disease. If you have a keen interest in bioinformatics and data science paired with coding experience, this cutting edge project can teach you big data analysis in the budding field of spatial transcriptomics.
spatial transcriptomics, data science, bioinformatics, skin, dermatology
Biochemistry and Molecular Biology
Masters by research
Top-up scholarship funding available
15 Innovation Walk