Anticancer activities from selected snake venom protein(s) on human cancer cells

Snake venom contains many bioactive molecules and toxins with potential therapeutic applications, including anti-cancer. Snake venom proteins such as L-amino acid oxidase (LAAO), Phospholipase A2, and Snake Venom Metalloproteinase (SVMP) were identified with potential anti-cancer activities in various human cancer cell lines. Our previous study on LAAO from Malaysian pit vipers demonstrated an anti-cancer potential via selective cytotoxic activity on human colorectal cancer cell lines and induction of apoptosis (1,2). The potential source of anti-cancer agents from Malaysian cobra venom has been reviewed and discussed (3) Key techniques (training will be provided): Cell culture and maintenance, protein purification (HPLC and FPLC), liquid chromatography-mass spectrometry. References: 1. Zainal Abidin, S.A.; Lee, Y.Q.; Othman, I.; Naidu, R. Malaysian Cobra Venom: A Potential Source of Anti-Cancer Therapeutic Agents. Toxins 2019, 11, 75. https://doi.org/10.3390/toxins11020075 2. Zainal Abidin, S.A.; Rajadurai, P.; Hoque Chowdhury, M.E.; Othman, I.; Naidu, R. Cytotoxic, Anti-Proliferative and Apoptosis Activity of l-Amino Acid Oxidase from Malaysian Cryptelytrops purpureomaculatus (CP-LAAO) Venom on Human Colon Cancer Cells. Molecules 2018, 23, 1388. https://doi.org/10.3390/molecules23061388 3. Zainal Abidin, S.A.; Lee, Y.Q.; Othman, I.; Naidu, R. Malaysian Cobra Venom: A Potential Source of Anti-Cancer Therapeutic Agents. Toxins 2019, 11, 75. https://doi.org/10.3390/toxins11020075