Anti-neutrophil cytoplasmic antibodies (ANCA) are generated when patients develop autoimmunity to various proteins expressed in immune cells. These autoantibodies are subsequently associated with the development of damaging inflammation in specific organs, including the kidney and lungs. While progress is being made in understanding how ANCA cause disease in the kidney, the mechanisms of ANCA-associated inflammation in the lung remain poorly understood. In this project, we will use advanced in vivo imaging to examine the pulmonary microvasculature with the aim of uncovering the effects of ANCA in the lung. Specifically, this work will examine the alterations in intravascular adhesive behaviour of neutrophils and other immune cells induced by ANCA, and how these changes lead to pulmonary inflammation and injury. In these experiments, skills will be developed in surgery, in vivo confocal imaging, flow cytometry and other immunological techniques.
kidney, autoimmunity, glomerulus, imaging, inflammation, intravital microscopy
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Medicine - Monash Medical Centre
Top-up scholarship funding available
Monash Medical Centre Clayton