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Anti-neutrophil cytoplasmic antibodies and pulmonary inflammation

Description 
Anti-neutrophil cytoplasmic antibodies (ANCA) are generated when patients develop autoimmunity to various proteins expressed in immune cells. These autoantibodies are subsequently associated with the development of damaging inflammation in specific organs, including the kidney and lungs. While progress is being made in understanding how ANCA cause disease in the kidney, the mechanisms of ANCA-associated inflammation in the lung remain poorly understood. In this project, we will use advanced in vivo imaging to examine the pulmonary microvasculature with the aim of uncovering the effects of ANCA in the lung. Specifically, this work will examine the alterations in intravascular adhesive behaviour of immune cells induced by ANCA, and how these changes lead to pulmonary inflammation and injury. In these experiments, skills will be developed in surgery, in vivo confocal imaging, flow cytometry and other immunological techniques.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
kidney, autoimmunity, glomerulus, imaging, inflammation, intravital microscopy
School 
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Medicine - Monash Medical Centre
Available options 
PhD/Doctorate
Honours
Time commitment 
Full-time
Part-time
Top-up scholarship funding available 
No
Physical location 
Monash Medical Centre Clayton

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