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Adiposity, oxidative stress & insulin resistance

Description 
Excess body weight is a major and leading factor in overall disease burden worldwide and if left unabated could lead to falls in overall life expectancy, particularly in developed nations such as the United States and Australia. In 2010 overweight and obesity were estimated to cause some 3.4 million deaths worldwide. Obesity is a key contributor to a myriad of human diseases including non-alcoholic fatty liver disease (NAFLD) and cancer. Moreover obesity is the single most important contributor to the development of type 2 diabetes, a major cause of obesity-associated morbidity and mortality. The environmental, epidemiological and socioeconomic factors underlying the development if obesity and type 2 diabetes are multifactorial and complex. Their increasing prevalence indicates that dietary and lifestyle interventions alone are unlikely to be effective in combating obesity and type 2 diabetes, and underscores the need for a better understanding of their aetiology and the development of novel therapeutic approaches. -------------------------------------------------------------------------------------------------------------------------------------------------------------- Obesity or increased visceral adiposity are causally linked to the development of insulin resistance, a state of diminished insulin responsiveness, which is the major etiologic factor of the metabolic syndrome and precedes the development of frank type 2 diabetes. The molecular processes underlying the development of insulin resistance remain unclear. Oxidative stress occurs when the generation of reactive oxygen species (ROS) exceeds the antioxidant capacity of the cell. Oxidative stress is thought to drive insulin resistance and type 2 diabetes. Projects are available to determine the mechanisms by which ROS contribute to the development of insulin resistance.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
diabetes, insulin resistance, metabolic syndrome, metabolic disease, health, biomedicine, obesity, fat, stress, biochemistry, molecular biology, Department of Biochemistry and Molecular Biology
School 
Biomedicine Discovery Institute (School of Biomedical Sciences) » Biochemistry and Molecular Biology
Available options 
PhD/Doctorate
Masters by research
Honours
Short projects
Time commitment 
Full-time
Top-up scholarship funding available 
No
Physical location 
Clayton

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