Amnion stem cells have reparative potential in the lung. It is yet unknown how the amnion cells trigger the regenerative process to improve lung function. We will use an animal model to mimic bronchopulmonary dysplasia and determine how amnion stem cell treatment can awaken the stem cell niche in the lung. Various techniques will be employed such as small animal surgery, stem cell culture, immunohistochemistry, ELISA, FACS, real-time PCR and western blotting. This project will provide valuable data on the mechanism of stem cell action as we progress this work to Phase I clinical trials.
amnion stem cells, regenerative medicine, lung function
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research
Top-up scholarship funding available
Monash Health Translation Precinct (Monash Medical Centre)