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Acquired epilepsy in Alzheimer’s disease

Alzheimer's disease (AD) patients are 10 times more likely to develop epilepsy compared with age-matched controls. The treatment of recurrent seizures with conventional antiepileptic drugs may exacerbate cognitive decline. There are currently no treatments that prevent epilepsy in AD patients and the pathological basis for the increased risk of epilepsy is largely unknown Understanding the pathomechanisms of epileptogenesis in AD is crucial in identifying effective therapeutic strategies. This will help to prevent the development of epilepsy in this high risk and vulnerable population. This project aims to directly address the mechanisms of epileptogenesis in AD through the study of animal models of AD and acquired epilepsy. The aims will be achieved by subjecting transgenic AD models reflecting the pathological hallmarks to acquired epileptogenesis and treating them novel compounds. The phenotypic changes will be correlated with the molecular and cellular changes in these pathways. This project is suitable for students with background in neuroscience.
Essential criteria: 
Minimum entry requirements can be found here:
Alzheimer's disease, Epilepsy, antiepileptic drugs, Translational, physiology, pharmacology, microbiology, anatomy, developmental biology, molecular biology, biochemistry, immunology, human pathology, clinical, neuroscience
Central Clinical School » Neuroscience
Available options 
Masters by research
Time commitment 
Top-up scholarship funding available 
Physical location 
Alfred Research Alliance
Assoc Prof 
Nigel Jones

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