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4. Effect of insulin therapy on body composition in type 2 diabetes. Effect on muscle mass and function and activation of muscle growth pathways.

The student would study patients with type 2 diabetes before and after the commencement of insulin therapy. Patients would be studied before and 6 months after the commencement of therapy using dual energy xray absorptiometry, bioelectrical impedance, and thigh muscle cross sectional area by CT. Blood tests a for biomarkers of muscle mass and muscle biopsies will also be taken. Skeletal muscle growth pathways will be studies using Western blots and quantitative PCR techniques.
Essential criteria: 
Minimum entry requirements can be found here:
Insulin, type 2 diabetes, skeletal muscle
Eastern Health Clinical School
Available options 
Time commitment 
Physical location 
Eastern Health Clinical School, level 2, 5 Arnold Street Box Hill 3128
Chris Gilfillan

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