Description
Systemic lupus erythematosus (SLE) and related autoimmune diseases remain incurable, with therapies largely directed at suppressing downstream inflammation rather than targeting disease‑maintaining mechanisms. Our pioneering studies have recently identified TLR7 as a key modulator of SLE (Brown et al. 2022 Nature; Alharbi et al. 2026 Nature Immunology). In this project we are exploring how aberrant TLR7 function can be targeted by short RNA fragments to limit auto-immunity, beyond the case of SLE. The successful candidate will gain cutting edge practical knowledge in molecular, cellular and animal biology, working on a project with a strong translational angle.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
immunology inflammation DNA Lupus
School
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Molecular and Translational Sciences
Available options
PhD/Doctorate
Masters by research
Honours
Time commitment
Full-time
Top-up scholarship funding available
No
Physical location
Monash Health Translation Precinct (Monash Medical Centre)
Co-supervisors
Dr
Sunil Sapkota