OPTIMA Study: Optimising maternal and perinatal outcomes through a digital clinical decision support tool in maternity care

Pregnancy complications lead to significant maternal and perinatal morbidity and mortality. The Fetal Medicine Foundation has developed prediction models to estimate, in the first, second and third trimesters of pregnancy, individual risks of pregnancy complications such as preterm birth, small-for-gestational age (SGA) neonates, preterm pre-eclampsia and term pre-eclampsia. In a partnership led by Griffith University (Gold Coast), we will recruit pregnant participants undergoing routine antenatal care and ultrasound examinations to i) evaluate the population impact of implementing first trimester screening for preterm pre-eclampsia and prevention with aspirin in the high-risk group and ii) validate models to predict preterm birth, SGA neonates, and term pre-eclampsia prediction in the third trimester to guide timing of birth.